Whenever underwear gets implemented it'd be cool to be able to buy/research a pair of vibrating panties, maybe with their own controls so you could either very slowly work your way to your orgasm or send yourself ( or the subject that's wearing them) rocketing over the edge. It would also be nice to be able to keep them going outside the lab, for some exhibitionism as you interact with your coworkers, desperately trying not to cum in your pants in front of them. The exhibition thing could also be applied to things like vibrating cock rings and clit vibes as well.

Just a thought to add a touch of light breath control element to the game over all. Maybe aphrodisiacs and such can be pumped through it and for limited breathplay having a timer for it. 

To have an option where you can choose if a character has only one or multiple parts like dicks or holes 

Pretty self explanatory, stimulate a subject by deeply "inspecting" their mouth with your hands, either before or after cuming inside 

As the header says I like the portals but it's not the most important thing and would probably be a bitch to program.

something like a electric slime/goo that we can stick to the breast, pussy penis to electrostimulate the characters

Just like RACK, have this available for use or have requested by subjects.

Half of the option is currently available in the game, this can also help keep some subjects busy if you like selecting more than one subject at a time

Just insert and work on the other subject till ready

it would be great for the ability to love on one's footpaws, and as for the growth/macro bit, perhaps a grow/shrink gun, with whatever slight limits if needed